Christine Brotschi : rechercher sur Z-Library

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Don't use scam websites

Livres
Articles (18)
Les plus populaires
Liste
- Liste
- Tableau

1

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

Boss, Christoph, Gatfield, John, Brotschi, Christine, Heidmann, Bibia, Sifferlen, Thierry, Raumer, Markus, Schmidt, Gunther, Williams, Jodi T., Treiber, Alexander, Roch, Catherine

Journal:

Année:

2020

Fichier:

PDF, 994 KB

2020

2

Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

Boss, Christoph, Roch-Brisbare, Catherine, Steiner, Michel A., Treiber, Alexander, Dietrich, Hendrik, Jenck, Francois, von Raumer, Markus, Sifferlen, Thierry, Brotschi, Christine, Heidmann, Bibia, Wil

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 816 KB

english, 2014

3

The quest for the best dual orexin receptor antagonist (daridorexant) for the treatment of insomnia disorders

Boss, Christoph, Gatfield, John, Brotschi, Christine, Heidmann, Bibia, Sifferlen, Thierry, von Raumer, Markus, Schmidt, Gunther, Williams, Jodi T., Treiber, Alexander, Roch, Catherine

Journal:

Année:

2020

Fichier:

PDF, 1.54 MB

2020

4

Ein stabiler DNA-Duplex mit einem nichtwasserstoffverbrückenden, nichtformkomplementären Basenpaar: Interstrang-Stapelwechselwirkungen als stabilitätsbestimmender Faktor

Christine Brotschi, Adrian Häberli, Christian J. Leumann

Journal:

Angewandte Chemie

Année:

2001

Langue:

german

Fichier:

PDF, 92 KB

german, 2001

5

A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor

Christine Brotschi, Adrian Häberli, Christian J. Leumann

Journal:

Angewandte Chemie International Edition

Année:

2001

Langue:

english

Fichier:

PDF, 91 KB

english, 2001

6

DNA mit hydrophobem Basen-Ersatz: ein stabiles reißverschlussartiges Erkennungsmuster durch Interstrang-Basen-Stapelwechselwirkungen

Christine Brotschi, Christian J. Leumann

Journal:

Angewandte Chemie

Année:

2003

Langue:

german

Fichier:

PDF, 112 KB

german, 2003

7

DNA with Hydrophobic Base Substitutes: A Stable, Zipperlike Recognition Motif Based On Interstrand-Stacking Interactions

Christine Brotschi, Christian J. Leumann

Journal:

Angewandte Chemie International Edition

Année:

2003

Langue:

english

Fichier:

PDF, 109 KB

english, 2003

8

Bipyridyl- and Biphenyl-DNA: A Recognition Motif Based on Interstrand Aromatic Stacking

Christine Brotschi, Gérald Mathis, Christian J. Leumann

Journal:

Chemistry - A European Journal

Année:

2005

Langue:

english

Fichier:

PDF, 253 KB

english, 2005

9

Transition Metal Ligands as Novel DNA-Base Substitutes

Christine Brotschi, Christian J. Leumann

Journal:

Année:

2004

Fichier:

PDF, 56 KB

2004

10

Pentafluorophenyl–Phenyl Interactions in Biphenyl-DNA

Alain Zahn, Christine Brotschi, Christian J. Leumann

Journal:

Chemistry - A European Journal

Année:

2005

Langue:

english

Fichier:

PDF, 116 KB

english, 2005

11

Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

Sifferlen, Thierry, Boller, Amandine, Chardonneau, Audrey, Cottreel, Emmanuelle, Hoecker, Johannes, Aissaoui, Hamed, Williams, Jodi T., Brotschi, Christine, Heidmann, Bibia, Siegrist, Romain, Gatfield

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 951 KB

english, 2014

12

Transition Metal Ligands as Novel DNA-Base Substitutes

Brotschi, Christine, Leumann, Christian J.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

2003

Langue:

english

Fichier:

PDF, 182 KB

english, 2003

13

RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes

Brotschi, Christine, Leumann, Christian J.

Journal:

Chemical Communications

Année:

2005

Langue:

english

Fichier:

PDF, 117 KB

english, 2005

14

Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

Williams, Jodi T., Gatfield, John, Roch, Catherine, Treiber, Alexander, Jenck, Francois, Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Heidmann, Bibia, Boss, Christoph

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 750 KB

english, 2015

15

The Morbidity and Mortality Conference in Pediatric Intensive Care as a Means for Improving Patient Safety

Frey, Bernhard, Doell, Carsten, Klauwer, Dietrich, Cannizzaro, Vincenzo, Bernet, Vera, Maguire, Christine, Brotschi, Barbara

Journal:

Pediatric Critical Care Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 418 KB

english, 2016

16

Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach

Heidmann, Bibia, Gatfield, John, Roch, Catherine, Treiber, Alexander, Tortoioli, Simone, Brotschi, Christine, Williams, Jodi T., Bolli, Martin H., Abele, Stefan, Sifferlen, Thierry, Jenck, François, B

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2016

17

Cover Picture: Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach (ChemMedChem 19/2016)

Heidmann, Bibia, Gatfield, John, Roch, Catherine, Treiber, Alexander, Tortoioli, Simone, Brotschi, Christine, Williams, Jodi T., Bolli, Martin H., Abele, Stefan, Sifferlen, Thierry, Jenck, François, B

Journal:

Année:

2016

Fichier:

PDF, 369 KB

2016

18

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs

Brotschi, Christine, Bolli, Martin H., Gatfield, John, Heidmann, Bibia, Jenck, Francois, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T., Boss, Christoph

Journal:

Année:

2020

Langue:

english

Fichier:

PDF, 3.34 MB

english, 2020